Iron and Infection: Molecular, Physiological and Clinical Aspects

Second Edition Iron and Infection Molecular, Physiological and Clinical Aspects Edited by J J Bullen University of Miami School of Medicine, USA, and E Griffiths World Health Organization, Geneva, Switzerland This revised edition covers major new advances made during the past decade on the role of iron in infection. These issues are of fundamental importance for understanding bacterial pathogenesis and resistance to infection, and are particularly relevant to present day circumstances in view of the progressive failure of antibiotics to control clinical infections. Topics covered are: Iron in biological systems Iron proteins The iron uptake systems of pathogenic organisms Iron as a regulatory signal Molecular genetics of iron transport as a component of virulence Iron and the immune system Iron binding proteins and host defence Clinical and physiological aspects Future prospects Sepsis is a global problem which requires urgent investigation, and this second edition of Iron and Infection will be essential reading for clinical microbiologists and infectious disease specialists.