World-famous "consulting detective" Sherlock Holmes faces a terrible crisis: a ring of criminal masterminds has threatened to loose thousands of plague-infected rats into the streets of London. But the Black Death isn't Holmes' only problem. A lone killer haunts the city. His calling card is a trail of corpses, drained of blood to the last drop.
The key to solving both crimes rests in the hands of a mysterious nobleman recently returned to London on a personal matter. His name is Dracula. The Count is quickly entangled in a web of evil that even his immortal powers may not be enough to breach. Holmes and Dracula soon come to the peculiar realization that they may be each other's only hope.