Schistosomes: Development, Reproduction and Host Relations

This work provides a unique, comprehensive, and up-to-date review of the biology of the parasitic flatworm, Schistosoma, which is responsible for one of the world's most pervasive infectious diseases, Schistisomiasis. The unusual characteristics of the organism, and the immediacy of its effect on human health, have combined to bring the schistosomes under considerable scrutiny in the field of parasitology. As parasites living within the circulatory systems of their vertebrate hosts, adult schistosomes face problems of reproduction and egg dispersal far beyond those of most animals. Yet despite their many apparent frailties, these organisms have developed mechanisms not only to survive, but to prevail and evolve into dangerous pathogens. This book concentrates on development and reproduction, since they are key to the parasite's existence and are particularly important because the disease in humans is induced by the worms' eggs rather than the organisms themselves. The book will aid those investigators who wish to apply advanced techniques to schistosomes, but who lack familiarity with their fundamental biology. It draws together findings on the main features of schistosome biology, pointing out areas of controversy and special significance, and topics in need of further work. The author is a recognized authority on schistosomiasis. His book will be an invaluable aid to all those involved in studying and treating the disease, including parasitologists, immunologists, molecular biologists, and public health specialists.