Reverse Genetics of RNA Viruses: Applications and Perspectives

Reverse genetics, the genetic manipulation of RNA viruses tocreate a wild-type or modified virus, has led to important advancesin our understanding of viral gene function and interaction withhost cells. Since many severe viral human and animal pathogens areRNA viruses, including those responsible for polio, measles,rotaviral diarrhoea and influenza infections, it is also anextremely powerful technique with important potential applicationfor the prevention and control of a range of human and animal viraldiseases.

Reverse Genetics of RNA Viruses provides a comprehensiveaccount of the very latest developments in reverse genetics of RNAviruses through a wide range of applications within each of thecore virus groups including; positive sense, negative sense anddouble stranded RNA viruses. Written by a team of internationalexperts in the field, it provides a unique insight into how thefield has developed, what problems are being addressed now andwhere applications may lead in the future. It will prove invaluableto bioscience, medical and veterinary students, those startingresearch in this area as well as other researchers and teachersneeding to update their knowledge of this fast-moving field. * An authoritative, comprehensive overview of reverse genetics inRNA Viruses. * Includes numerous examples of cutting- edge applications ofreverse genetics within each of the RNA viral groups. * Written by a team of international experts, including some ofthe leading researchers in the field.