Nitrosamines and Related N-Nitroso Compounds: Chemistry and Biochemistry (ACS Symposium Series)

Presents recent advances in prevention of nitrosamine formation in vitro and in vivo. Discusses mechanisms of N-nitroso compound formation and denitrosation. Reviews the metabolism of nitrosamines and the modification of DNA and proteins by the products of metabolism. Examines the effects of dietary components and other chemopreventive agents on N-nitroso compound metabolism and carcinogenicity. Discusses the use of specific biomarkers of nitrosamine exposure in humans and in animal models and covers their role in the molecular epidemiology of tobacco-derived nitrosamines.