Genome Analysis : A Laboratory Manual : Mapping Genome (Genome Analysis Series, Vol 4)

The final volume in the series of practical laboratory manuals providing newcomers and experienced researchers with theoretical background, laboratory protocols, and resource material for analyzing genes and genomes. Assuming only a basic knowledge of molecular biology, explains how to clone, manipulate, analyze, and sequence large segments of DNA and to relate expressed sequence to phenotype variations. Covers meiotic mapping in humans, genetic and comparative mapping in mice, identifying and analyzing DNA polymorphisms, DNA markers for physical mapping, representational difference analysis, somatic cell genetics and radiation hybrid mapping, and fluorescence in-situ hybridization. The articles are by Cold Harbor Springs course instructors, who in many cases are the creators of the methods they describe. Plastic comb binding. The CiP data shows the lead editor as Eric D. Green. Annotation c. by Book News, Inc., Portland, Or.