Clinical Applications of Capillary Electrophoresis (Methods in Molecular Medicine)

Stephen M. Palfrey brings together for first time a collection of detailed capillary electrophoresis protocols designed exclusively for clinical applications. Written by the leading scientists who have often perfected these methods in their own laboratories, the protocols furnish new and more powerful assays for many routine serum and blood tests now regularly performed in clinical laboratories, including serum and urine proteins, hemoglobin separation, and the detection of CSF proteins, lipoproteins, myoglobin, cryoglobulins, and cathepsin D. The protocols offered for DNA analysis include double-stranded DNA analysis, the prenatal diagnosis of Down's syndrome, Rh D/d genotyping, the identification of mutated p53 oncogene, and the detection of microstaellite instability in cancers. Many of the methods can be automated to replace more labor intensive and costly tests that are currently used in most clinical laboratories. Clinical Applications of Capillary Electrophoresis demonstrates clearly the simplicity, versatility, and power of CE over conventional methods.