The Journal of Cancer Research, Vol. 1 (Classic Reprint)

Excerpt from The Journal of Cancer Research, Vol. 1

In 1907 Loeb showed that it is possible to produce "transitory" uterine tumors in various animals through the coordinated action of an internal secretion of the corpus luteum and of mechanical factors.1 These new formations, which had the structure of maternal placenta, were described as deciduomata or placentomata, in order to indicate their tumor-like character, and to emphasize the significance of such experiments for the analysis of tumor growth. They were described as "transitory" tumors because retrogressive changes set in after a certain time, and the newly formed tissue finally became necrotic. The possible significance of internal secretions (hormones) in the origin of cancer has been subsequently discussed by Loeb and others (von Hansemann, Isaac Levin, Apolant), though it has not been possible to offer any direct proof of such a relationship.

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