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Califano shows how substance abuse is the culprit in violent and property crime, soaring Medicare and Medicaid costs, family breakup, domestic violence, the spread of AIDS, teen pregnancy, poverty, and low productivity. He takes on alcohol and tobacco interests that buy political protection with campaign contributions and seed a culture of substance abuse among our nation's children and teens. He explains the importance of parent power, proposes revolutionary changes in prevention, treatment, and criminal justice, and calls upon every individual and institution to confront this plague that has maimed and killed more Americans than all our wars, natural catastrophes, and traffic accidents combined.