Antithrombotic Therapy

This is a clinically oriented guide to antithrombotic therapy. A presentation of the pathophysiology of the coagulation system is included, along with a detailed discussion of the pharmacology of various anti-clotting agents, including antithrombins, plasminogen activators, and antiplatelet agents. The clinical applications of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute myocardial infarction, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease, (venous thromboembolic disease and pulmonary embolism) are presented. The authors review the results of major clinical trials of antithrombotic therapy and their implications for clinical practice. The text discusses antithrombotic drug options in various clinical situations, including combination therapy. Proper monitoring of antithrombotic therapy is presented, along with complications of antithrombotic therapy and their management.