New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

This volume is based on the international workshop on "New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives of Estrogen Therapy" held in Berlin, 5-7 March, 2003. Researchers from industry and leading academic laboratories describe recent findings on the mechanisms of estrogen action via different ER subtypes, the interaction of ERs with different cofactors, and the action of ERs through different pathways including non-genomic mechanisms. Furthermore, the book provides information on (a) the biological functions of the two ER subtypes, ERa and ERb, as concluded from different gene-knockout models, (b) the design and synthesis of new selective estrogens, and (c) possible clinical applications for new selective estrogens. All chapters are written by leading experts in the field, who survey and summarize the approaches and findings of different companies and institutions. The book gives the reader a balanced and up-to-date view of new developments in the field of estrogens.