Molecular Biology of the Gene

Now completely up-to-date with the latest research advances, the Seventh Edition of James D. Watson’s classic book, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly distinguished biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.
Features:
Balanced coverage of prokaryotic and eukaryotic systems is included.
To support the concise narrative, additional material can be found in essay boxes that are labeled in four categories:
Key or Classic Experiments highlight influential experimental strategies that show students how we know what we know.
Techniques include recent methods from the fields of bioinformatics and genomics.
Advanced Concepts provide further discussions of key theories and principles.
Medical Connections highlight how understanding basic mechanisms sheds light on—and may lead to treatment of—medical conditions and human diseases.
Contents:
I. History
1. Mendelian View of the World
2. Nucleic Acids Convey Genetic Information

II. Structure and Study of Macromolecules
3. Weak and strong chemical bonds.
4. The Structure of DNA
5. The Structure of RNA
6. The Structure of Proteins and Protein: Nucleic Acid Interactions
7. Techniques of Molecular Biology

III. Maintenance of the Genome
8. Genome Structure, Chromatin and the Nucleosome
9. The Replication of DNA
10. The Mutability and Repair of DNA
11. Homologous Recombination at the Molecular Level
12. Site Specific Recombination and Transposition of DNA

IV. Expression of the Genome
13. Mechanisms of Transcription
14. RNA Splicing
15. Translation
16. The Genetic Code
17. Origins and early evolution of life

V. Regulation
18. Transcriptional Regulation in Prokaryotes
19. Transcriptional Regulation in Eukaryotes
20. Regulatory RNAs
21. Gene Regulation in Development and Evolution
22. Systems Biology

Appendix:
Model Organisms