The Human SDF1 Gene Polymorphism is located on a mutational hot spot that was identified by the Hominoid Genome study (1).(Statistical Data Included): An article from: Human Biology
Book Details
Author(s)Ryosuke Kimura, Takafumi Ishida
PublisherWayne State University Press
ISBN / ASINB0008IMCUK
ISBN-13978B0008IMCU8
AvailabilityAvailable for download now
MarketplaceUnited States 🇺🇸
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This digital document is an article from Human Biology, published by Wayne State University Press on December 1, 2001. The length of the article is 1464 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: Abstract Nucleotide sequences of a part of the stromal cell-derived factor-1 (SDF-1) gene 3' untranslated region were studied among hominoids (chimpanzees, gorillas, orangutans and gibbons). An identical sequence to the human SDF1-3'G allele was found in chimpanzees and gibbons, whereas that to the 3'A allele was found in gorillas. Based on the sequence data and the hominoid phylogenetic relation, it was suggested that an adenine nucleotide at nucleotide position (np) 801 in humans and gorillas was independenfly introduced into each lineage after the specific divergence and an ancestral hominoid sequence of this site (np 799-802) was deduced as CCGG. The present data showing a mutational hot spot on this site suggest the possible presence of multiple origins of the worldwide distribution of the SDF1-3'A allele in humans.
Citation Details
Title: The Human SDF1 Gene Polymorphism is located on a mutational hot spot that was identified by the Hominoid Genome study (1).(Statistical Data Included)
Author: Ryosuke Kimura
Publication:Human Biology (Refereed)
Date: December 1, 2001
Publisher: Wayne State University Press
Volume: 73 Issue: 6 Page: 891(5)
Article Type: Statistical Data Included
Distributed by Thomson Gale
From the author: Abstract Nucleotide sequences of a part of the stromal cell-derived factor-1 (SDF-1) gene 3' untranslated region were studied among hominoids (chimpanzees, gorillas, orangutans and gibbons). An identical sequence to the human SDF1-3'G allele was found in chimpanzees and gibbons, whereas that to the 3'A allele was found in gorillas. Based on the sequence data and the hominoid phylogenetic relation, it was suggested that an adenine nucleotide at nucleotide position (np) 801 in humans and gorillas was independenfly introduced into each lineage after the specific divergence and an ancestral hominoid sequence of this site (np 799-802) was deduced as CCGG. The present data showing a mutational hot spot on this site suggest the possible presence of multiple origins of the worldwide distribution of the SDF1-3'A allele in humans.
Citation Details
Title: The Human SDF1 Gene Polymorphism is located on a mutational hot spot that was identified by the Hominoid Genome study (1).(Statistical Data Included)
Author: Ryosuke Kimura
Publication:Human Biology (Refereed)
Date: December 1, 2001
Publisher: Wayne State University Press
Volume: 73 Issue: 6 Page: 891(5)
Article Type: Statistical Data Included
Distributed by Thomson Gale
