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Elevated mutation rates in the germline of Pol@k mutant male mice [An article from: DNA Repair]
Book Details
Publisher
Elsevier
ISBN / ASIN
B000P6NZTW
ISBN-13
978B000P6NZT6
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Description
This digital document is a journal article from DNA Repair, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Pol@k^-^/^-) deficient mice. The spontaneous mutation rate in homozygous Pol@k^-^/^- males was significantly higher than in isogenic wild-type mice (Pol@k^+^/^+), but the ESTR mutation spectrum in Pol@k^-^/^- animals did not differ from that in Pol@k^+^/^+ males. We suggest that compromised translesion synthesis in Pol@k^-^/^- mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.
Description:
Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Pol@k^-^/^-) deficient mice. The spontaneous mutation rate in homozygous Pol@k^-^/^- males was significantly higher than in isogenic wild-type mice (Pol@k^+^/^+), but the ESTR mutation spectrum in Pol@k^-^/^- animals did not differ from that in Pol@k^+^/^+ males. We suggest that compromised translesion synthesis in Pol@k^-^/^- mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.
