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Determination and antioxidant activity evaluation of etodolac, an anti-inflammatory drug, by sequential injection analysis [An article from: Analytica Chimica Acta]
Book Details
PublisherElsevier
ISBN / ASINB000PDT8SC
ISBN-13978B000PDT8S4
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MarketplaceUnited States 🇺🇸
Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
A robust, accurate and sensitive automated procedure for the determination of etodolac, an anti-inflammatory drug, in pharmaceutical formulas by sequential injection analysis, is reported. The same system was also applied to evaluate the antioxidant activity of the drug expressed as Trolox equivalent antioxidant capacity (TEAC). The methodology is based on measuring at 734nm the decay of absorbance of a solution with the radical 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS?^+) after its reduction by etodolac. Optimum ABTS?^+-etodolac reaction was achieved with 0.329mL of sample and 0.205mL of ABTS?^+ solution. Etodolac was determined at concentrations up to 4.5x10^-^5molL^-^1. A solution detection limit of 6.6x10^-^6molL^-^1 was obtained under the optimised experimental conditions. A relative standard deviation (n=10) lower than 4.7% with a sample throughput of more than 21 samples/h was obtained. No interference from excipients was observed. The developed methodology was applied in the analysis of pharmaceutical preparations and the obtained results were in good agreement with those furnished by the reference procedure with relative deviations lower than 1.4%.
Description:
A robust, accurate and sensitive automated procedure for the determination of etodolac, an anti-inflammatory drug, in pharmaceutical formulas by sequential injection analysis, is reported. The same system was also applied to evaluate the antioxidant activity of the drug expressed as Trolox equivalent antioxidant capacity (TEAC). The methodology is based on measuring at 734nm the decay of absorbance of a solution with the radical 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS?^+) after its reduction by etodolac. Optimum ABTS?^+-etodolac reaction was achieved with 0.329mL of sample and 0.205mL of ABTS?^+ solution. Etodolac was determined at concentrations up to 4.5x10^-^5molL^-^1. A solution detection limit of 6.6x10^-^6molL^-^1 was obtained under the optimised experimental conditions. A relative standard deviation (n=10) lower than 4.7% with a sample throughput of more than 21 samples/h was obtained. No interference from excipients was observed. The developed methodology was applied in the analysis of pharmaceutical preparations and the obtained results were in good agreement with those furnished by the reference procedure with relative deviations lower than 1.4%.
