Multi-generational effects of four selected environmental oestrogens on Daphnia magna [An article from: Chemosphere]

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Description:
The objective of this study was to determine whether vertebrate-type oestrogens have ecotoxicological effects on a crustacean species. The effects of 17@b-oestradiol (E2), diethylstilbestrol (DES), bisphenol A (BPA) and 4-nonylphenol (4-NP) on the freshwater invertebrate Daphnia magna were assessed over first and second generations. The acute EC"5"0 48h, based on immobilisation, for E2, DES, BPA and 4-NP were 2.87mg/l, 1.55mg/l, 7.75mg/l and 0.13mg/l, respectively. The impact of the test chemicals on moulting frequency was also assessed. The EC"5"0 48h, based on the inhibition of moult number for E2, DES and 4-NP were 2.04mg/l, 1.87mg/l and 0.14mg/l, respectively. BPA was not observed to impact the moulting frequency of D. magna at concentrations tested. In a series of separate studies, the effects of the four selected test compounds on the survival, moulting frequency and reproduction of first and second generational D. magna were assessed over a period of 21d. Exposure of D. magna to 4-NP decreased the number of offspring produced in both first and second generation testing. DES proved to have no significant (p=