This multimedia eBook examines best practices for the differential diagnosis and opioid-based management of breakthrough pain—ie, transient, functionally impairing pain flares that often interfere with good treatment outcomes for patients with chronic pain. Expert faculty address practical approaches to patient assessment, principles of responsible opioid prescribing, and appropriate roles for transmucosal immediate-release fentanyl medications. Complete this multimedia eBook to earn 1.0 CME Credit.