Genomics Orientations for Personalized Medicine (Frontiers in Genomics Research Book 1)

This e-Book is a comprehensive review of recent Original Research on Genomics and Individualized Medicine and related opportunities for Targeted Therapy written by Experts, Authors and Writers. The results of Original Research are gaining value added for the e-Reader by the Methodology of Curation. The e-Book’s articles have been published on the Open Access Online Scientific Journal, since April 2012.

As the reader takes this journey in reading, there will be an “emergence” and discovery that our thinking about the genome and genetics has fundamentally changed with a convergence of biophysics, chemistry, biology, medicine, and biotechnology ad bioengineering with a compression of the “OMICS” as a result of a realization of the evolutionary consistency of retained functions in cell substructure over long stretches of time and across species, and the major function of chromatin structure takes on a regulatory role, far exceeding the simple Watson-Crick and early translational models (DNA to RNA to protein; mRNA and ER; mitochondrion; lysosome). This becomes clearer when we examine how disturbances arise by small mutational changes in non-coding DNA as well as coding DNA that result in what we have always considered “disease”.