Histamine in Normal and Cancer Cell Proliferation

This volume in the series "Advances in the Biosciences" provides a review of the role of histamine in normal and cancer cell proliferation and summarizes the research carried out in this field over the last 40 years. Regarding the involvement of histamine in normal cell proliferation, the book describes, for the first time, its role in intestinal adaptation after massive bowel resection. The reader will find a definition of a new histamine receptor which explains the role of intracellular histamine in cancer development. Furthermore, this work deals with the recently recognized condition of histamine producing endocrine tumours. A chapter is devoted to the clinical application of certain histamine metabolytes as tumour markers. The book also presents the latest results of several clinical studies which demonstrate the efficacy of H2-receptor antagonists as adjuvant cancer treatment as well as the clinical use of the drug - DPPE - which blocks the intracellular histamine receptors.