The Legacy of Cell Fusion (Oxford Science Publications)

In order to study the genetics of somatic animal cells, Henry Harris and his colleagues invented the powerful method of viral-induced animal cell fusion. This volume evaluates the impact of cell hybridization on the study of cell differentiation, gene mapping, gene regulation, and the development of monoclonal antibodies. The book details important studies on nuclear structure and function, intracellular transport, membrane protein mobility, and nuclear-cytoplasmic interactions in heterokaryons and other cells. Tumor-suppressor genes and the role of radiation-hybrid mapping in the analysis of genetic tumors are also discussed. The book concludes with a chapter by Henry Harris which addresses a number of unsolved questions that remain regarding the link between cell growth and differentiation. Students and researchers in molecular genetics and cell, molecular, and cancer biology will welcome this fascinating overview of cell fusion research.