Neoplastic Transformation in Human Cell Culture: Mechanisms of Carcinogenesis (Experimental Biology and Medicine)

Rhim and Dritschilo's state-of-the-art volume on Neoplastic Transformation in Human Cell Culture highlights the latest findings on the role of carcinogenic agents in the development of human cancers using a variety of human cells as experimental model systems.

Chapters cover all the latest results on the transformation of human cells in culture and provide new insight into the molecular and cellular changes that occur during their conversion from normal to neoplastic states. A wealth of topics is presented, including: oncogenes • derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems • viral transformation • factors that trigger or affect cell transformation • in vitro model systems for viral, chemical, and radiation carcinogenesis • the multistep nature of human carcinogenesis • the role of activated and suppressor oncogenes in neoplastic transformation • cell aging • radiation transformation.

Unique in both scope and focus-devoted solely to human cell transformation systems- Neoplastic Transformation in Human Cell Culture provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!