Molecular Structure and Function of the Tight Junction: From Basic Mechanisms to Clinical Manifestations, Volume 1165 (Annals of the New York Academy of Sciences)

Aim of this volume is to clarify the relationship between molecularstructure and function of tight junction proteins, as well as theirregulation and their role in diseases. Current research may form abasis for future diagnostic and therapeutic approaches to diseaseswhich seem to have not much in common but are characterized bydefects of organ barriers, like Crohn's disease, renalhypertension, inner ear deafness, and cancerous diseases.

Topics include the functions of distinct tight junction proteinsas barrier or channel formers for solutes and water,characteristics of the tight junction in inflammatory boweldiseases, posttranslational modifications of tight junctionproteins, the relation between renal tight junction proteins andblood pressure control, and the molecular structure ofclaudin-claudin interactions

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