Locksie grew up in the church-against her will-thanks to her holier than thou mother. But now that she's all grown-up, she's her own woman and church is the last thing on her mind; her live-in boyfriend, Dawson, is the first. When Locksie finally decides to go back and visit church upon the invitation of her aunt, who hoped that by extending the invite, her niece would find God again, Locksie ends up finding more than she could have ever expected.
Hannah is Locksie's friend who has issues of her own. She's struggling to forgive her husband for the affair he had, while at the same time be a stepmother to the child who is a result of his affair. And all while the child's mother taunts Hannah every chance she gets.
In Me, Myself & Him, the characters are torn between holding on to the person they believe is the love of their life, or having to let go for the one thing that s missing from their life.