The Tarzan Twins, two schoolboys, Dick and Doc, are cousins who resemble each other because their mothers are twins. As Dick is also related to Tarzan through his father, they become known as the Tarzan Twins.
Invited to visit Tarzan's African estate, they become lost in the jungle and are imprisoned by cannibals, from whom they escape. They are then reunited with their host, who introduces them to his pet lion, Jad-bal-ja.
Subsequently, they become involved in an adventure involving exiles from the lost city of Opar, who have kidnapped Gretchen von Harben, the daughter of a missionary.