Particle-Particle Adhesion in Pharmaceutical Powder Handling

This work describes the physical principles of adhesion between particles and surfaces. These principles are applied to pharmaceutical processes involved in the manufacture of solid dosage forms such as powder, granules, tablets and dry powder inhalations. To help in the understanding of the physical properties of solid surfaces, an introduction to the theory of friction is given, and techniques for measuring particle adhesion and fracture mechanical properties of powders are introduced, as far as these are relevant to the processes discussed.