Hypothetical Proteins: Proteomic and Bioinformatic Interplay: Identification, Characterization and Functionality

In recent years, proteomics including mass spectrometry-based technologies become method of choice for detection of new proteins including biomarkers as well for pathway discovery in large-scale. The role of bioinformatics is one of unrecognized issues in proteomics. For correct definition, identification and detection of hypothetical proteins (HPs) as well as experimental characterization of these proteins, bioinformatic plays an essential role. In this book, the basics of bioinformatics in proteomics are discussed and several practical examples are given to understand the importance of proteomic methodology together with bioinformatic tools for identification as well as characterization of HPs.