Perforation Repair with Dental Pulp Stem Cells and DMP1: A New Approach to Repair Teeth Perforations Utilizing Dental Pulp Stem Cells and Dentin Matrix Protein 1 An Animal Model

Perforations due to iatrogenic errors can compromise the tooth prognosis. There is still no ideal endodontic material in the market to be used in a perforation site. This study evaluates the ability of Dental Pulp Stem Cells (DPSCs) and Dentin Matrix Protein 1 (DMP1) impregnated within a collagen scaffold to induce dentin formation in a furcal perforation site. Under the conditions of this study, it may be concluded that DPSCs impregnated within a collagen scaffold can differentiate into odontoblast-like cells secreting a highly cellular, vascular, and mineralized matrix that can be the ground substance for dentin formation, in the presence of DMP1.