Transdermal Drug Delivery System: Basic Concept, Enhancing techniques and Advanced Technology

Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism. Emulsions, Sub Saturated Reservoir System, True Solution, Gels and product are used for enhancing drug delivery across skin. Recent techiques are used like iontophoresis, ultrasound, poweject devices, macroflux, trasferosomes and laser radiation. New dosage forms are essential for other drugs in order to enhance the performance by reducing their dose, increasing absorption, delivering to the target site etc. The patented innovations in transdermal drug delivery arena aim at these goals. However, the ultimate test that an innovative technique should pass relates to its successful performance in vivo. Hence, the formulator faces a challenging task of translating the patented claims to actual practice.