Hot Melt Extrusion: Introduction, Characteristics, Excipients & Application

Hot Melt Extrusion can be simply defined as the process of forming a new material by forcing it through an orifice or die under controlled conditions, such as temperature, mixing, feed-rate and pressure. Hot Melt Extrusion is the process of embedding drug in a polymeric carrier. Hot Melt Extrusion is the process of converting a raw material into a product of uniform shape and density by forcing it through a die under controlled conditions. In recent years, interest in hot melt extrusion techniques for pharmaceutical applications has grown significantly. Hot melt extrusion (HME) is an established manufacturing process that has been used in the plastics and food industry since the 1930s. It was first developed in the early 20th century by the plastics industry as a means of producing different shapes for a variety of industrial and domestic applications.