Biological evaluation of some 2,5-disubstituted-1,3,4-oxadiazoles: Synthesis, Biological evaluation of some novel 2,5-Disubstituted-1,3,4-Oxadiazoles containing furan moiety

2-5-disubstituted 1,3,4-oxadiazoles constitute a unique class of nitrogen and oxygen containing 5-membered hetero cycles. During the past years considerable evidence also accumulate to demonstrate the efficacy of 1,3,4-oxadiazoles including anti-malarial, anti-bacterial, anti-inflammatory and other biological activities. In an attempt for the enhancement of biological activity incorporation of 1,3,4-oxadiazoles was made with furan moiety. The main objective was to synthesize various 2,5-disubstituted-1,3,4-oxadiazoles, which were characterized by different spectroscopic techniques (IR,NMR,MASS). Analysis of spectral data of all the compounds revealed the successful formation of Different derivatives derived from 2,5-disubstituted-1,3,4-oxadiazoles and antibacterial and anti-inflammatory activities were evaluated.