(AC)n Dinucleotide repeat polymorphism in 5' [beta]-globin gene in native and Mestizo Mexican populations. (Brief Communications).(Statistical Data Included): An article from: Human Biology

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From the author: Abstract Repeated sequences are dispersed along the human genome. These sequences are useful as markers in diagnosis of inherited diseases, in forensic medicine, and in tracking the origin and evolution of human populations. The (AC)n repeated element is the most frequent in the human genome. In this paper, the (AC)n repeated element located in the 5' flanking region of the [beta]-globin gene was studied by single-strand conformation polymorphism (SSCP). Four ethnic Mexican groups (Mixteca, Nahua, Otomi, Purepecha) and a Mestizo population were analyzed. We observed three alleles, A [[(AC).sub.16]], B [[(AC).sub.14]], and C [[(AC).sub.18]], with a frequency of between 68.2% and 86.9%, 13.1% and 18.2%, and 6.7% and 13.7%, respectively. Allele C was present only in Purepecha and Mestizo groups. The absence of this allele in the other ethnic groups studied suggests that there is low genetic admixture of Purepecha and that this is a relatively isolated population. However, it could be that the C allele occurs in low frequencies in the other groups as a result of small sample sizes. The (AC)n repeat polymorphism in the [beta]-globin gene has not been previously studied in Amerindian populations.

Citation Details
Title: (AC)n Dinucleotide repeat polymorphism in 5' [beta]-globin gene in native and Mestizo Mexican populations. (Brief Communications).(Statistical Data Included)
Author: Rosenda Penaloza
Publication:Human Biology (Refereed)
Date: December 1, 2001
Publisher: Wayne State University Press
Volume: 73 Issue: 6 Page: 885(6)

Article Type: Statistical Data Included

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