Simultaneous determination of guanosine and guanosine-5'-triphosphate in biological sample using gold nanoparticles modified indium tin oxide electrode [An article from: Analytica Chimica Acta]

This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
A nanogold modified indium tin oxide (ITO) electrode was used for the simultaneous determination of guanosine and GTP at pH 7.2. The electrode exhibited an effective catalytic response towards their oxidation and lowered the oxidation potential of guanosine by ~120mV and GTP by ~183mV. Linear concentration curves were obtained for guanosine with a detection limit of 9.8x10^-^8M and 5.5x10^-^8M for GTP. The concentration of guanosine and GTP were also estimated in the human blood plasma samples using gold nanoparticles modified ITO electrode with good reproducibility.