Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to ^7Li-beam (LET=60keV/@mm) and correlation of their survival dynamics to ... Toxicology and Environmental Mutagenesis]

This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2007. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Chinese hamster V79 cell and a cell strain M5, derived from V79 cells and reported to be relatively resistant to @c-ray, hydrogen peroxide, and N-methyl-N-nitro-N-nitrosoguanidine (MNNG; a potent human carcinogen), were exposed to high LET ^7Li-beam (LET=60keV/@mm) at ~90% confluent state in the dose range of 0-1Gy. Effects of ^7Li-beam exposure on cell survival, micronuclei induction (MN), chromosomal aberrations (CA) and apoptosis were compared in both the cell lines. A dose-dependent decline in survival for both the cell lines was noted, relatively less in M5 cells (mostly p