Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation [An article from: Analytica Chimica Acta]

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Description:
A quantitative method for finasteride by liquid chromatography (LC) with UV detector, was validated for its new tablet form Dilaprost^(R). Analysis was performed using Nova Pak C"1"8 column at 60^oC. Detection was carried out at a wavelength of 210nm. The best separation for finasteride peak was achieved by isocratic elution with the mobile phase water/acetonitrile/tetrahydrofuran (80/10/10, v/v/v) and flow rate of 2mLmin^-^1. The sample volume injected into liquid chromatography system was 15@mL. Analytical method validation tests were performed.