Receptor Autoradiography: Principles and Practice (Oxford Science Publications)

Receptor autoradiography is an invaluable technique that is widely used to localize and characterize peptide and neurotransmitter binding sites. Its extensive use reflects the utility of the technique and the important advantages it offers over conventional biochemical procedures. This instructive work makes receptor autoradiography more accessible by giving a detailed account of the methodology and its application in the analysis of receptors in the brain and peripheral organs. These examples are not exhaustive but illustrate the versatility of the technique as well as its potential pitfalls. The book provides an introduction to the receptor concept and gives detailed information on the theory and procedures involved in the autoradiographic localization and quantification of radiolabelled ligand binding sites. This volume will be an essential tool for neuroscientists, pharmacologists, histochemists, neuropathologists, researchers in the pharmaceutical industry, and students of the biological sciences.