Communication within Animal Cells

The ordered growth and functioning of animal cells requires the transfer of information from one part of the cell to another. This information comes from a bewildering variety of sources, both within and outside the cell. Hormones, neurotransmitters, growth factors and extracellular metabolites interact with specific receptors on the plasma membrane or in the cytoplasm. Inside the cell, information is relayed by intracellular messengers, including cyclic nucleotides, inositol polyphosphates, diacylglycerol and calcium, and by G.T.P.-binding proteins, protein kinases, and D.N.A.-binding proteins. Finely balanced interactions between these different signalling pathways ensure that the required response occurs, and abnormalities in any of the components of the system can lead to a variety of diseases, including cancer. This textbook brings together and puts into perspective a large body of knowledge about intracellular signalling systems. Written in a clear and authoritative style, with many illustrations, it will be invaluable to students on advanced undergraduate and graduate courses. It also provides a detailed introduction to and review of this central topic for researchers in cell biology and related disciplines.