Biomolecular NMR Spectroscopy

The technique of nuclear magnetic resonance (N.M.R.) spectroscopy is an important tool in biochemistry and biophysics for the understanding of the structure and, ultimately, the function of biomolecules. This textbook explains the salient features of biological N.M.R. spectroscopy to undergraduates and postgraduates taking courses in N.M.R., 4iological N.M.R., physical biochemistry, and biophysics. Unlike other books in the general field of N.M.R. (except the advanced treatises), the approach here is to introduce and make use of quantum mechanical product operators as well as the classical vector method of explaining the bewildering array of pulse sequences available today. The book covers two-dimensional, three-dimensional, and four-dimensional N.M.R., and their application to protein and D.N.A. structure determination. A unique feature is the coverage of the biological aspects of solid-state N.M.R. spectroscopy. The author provides many selected examples from the research literature, illustrating the applications of N.M.R. spectroscopy to biological proteins.