Pt. 1 Principles of Medical Practice 1 Infection and immune failure 3 2 Drug therapy 147 3 Poisoning 165 4 Critical care 185 5 Oncology 213 6 Palliative care and pain management 227 7 Frail older people 237 8 Medical psychiatry 245 9 Water, electrolyte and acid-base imbalance 271 10 Nutritional, metabolic and environmental disease 297 11 Clinical genetics 337 Pt. 2 System-Based Diseases 12 Cardiovascular disease 357 13 Respiratory disease 483 14 Kidney and genitourinary disease 575 15 Diabetes mellitus 641 16 Endocrine disease 683 17 Alimentary tract and pancreatice disease 747 18 Liver and bilary tract disease 831 19 Blood disorders 889 20 Musculoskeletal disorders 957 21 Skin disease 1049 22 Neurological disease 1103 23 Appendix 1211 Picture, box and table credits 1223 Index 1225