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This volume is intended to bridge the gap that has emerged between science and engineering in the field of advanced biological wastewater treatment. Information is provided about methods which became available in recent years, both in microbiology and computer based modeling and simulation. Various authors elucidate the essence of the newly developed methods, the potentials these methods have in gaining better understanding of complex microbial systems, and the advantages which are envisioned with respect to optimization of biological wastewater treatment plants, trouble shooting and innovation.