ASME STP-PT-065 - Branch Leg Study for Bioprocessing Equipment

The purpose of this document is to provide information on the flow conditions required to displace air from piping branches in a timely manner. When air is displaced from the branched fitting, the cleaning solution comes in contact with the branched piping components being cleaned-in-place (CIPed) and effective cleaning can occur. Without contact of CIP solutions, there is no cleaning. Note: The actual cleaning of process piping is more complicated than simply supplying an adequate flow rate (it involves many other factors such as the reagent concentration, temperature, contact time, etc.) and cleaning processes are outside of the scope of this document. The focus of this document is on the flow conditions required to ensure contact of the cleaning solution with the branched fittings - a key requirement for cleaning.