Extracellular Matrix: Chemistry: Biology, and Pathobiology with Emphasis on the Liver

Describing state-of-the-art research techniques for clinicians and introducing important clinical perspectives for basic scientists, this reference examines some significant areas of investigation into the biology of the extracellular matrix and its implications in human pathophysiology.;Focusing on the liver and providing a broad survey of the latest information available, Extracellular Matrix: discusses a wide range of models and organ systems; presents pathophysiological studies emphasizing hepatic disease, particularly the development of fibrosis and cirrhosis; furnishes structure and function analyses of the major extracellular matric components, including collagens, laminin, fibronectin, and proteoglycans; delineates the mechanisms leading to increased depositions of the matrix proteins during hepatic fibrogenesis; details new therapeutic approaches to liver disease; and more.;With authoritative contributions from more than 40 leading international experts representing five countries, Extracellular Matrix should be a useful reference for all scientists interested in matrix biology, chemistry, or pathobiology, especially gastroenterologists, hepatologists, pathologists, and graduate and medical school students in these disciplines.