Antimicrobial resistance: hearing before a subcommittee of the Committee on Appropriations, United States Senate, One Hundred Sixth Congress, second session, special hearing

OCLC Number: (OCoLC)45881967 Subject: Antibiotics -- Effectiveness. Excerpt: ...nter for the Development of Natural Products; Dr. Merle Sande, Professor and Chairman of the Department of Medicine at the University of Utah School of Medicine; Dr. Martin Rosenberg, Senior Vice President and Director of Anti-Infectives at SmithKline Beecham Pharmaceuticals; and Dr. Mark Nelson, Senior Director of Chemistry at Paratek Pharmaceuticals. Our witnesses have submitted statements to the committee, which will be made a part of the record in full, and the National Institutes of Health has also submitted a statement, which will be made a part of the record. STATEMENT OF JEFFREY P. KOPLAN, M.D., DIRECTOR, CENTERS FOR DISEASE CONTROL AND PREVENTION, DEPARTMENT OF HEALTH AND HUMAN SERVICES Senator Cochran. Let us begin with Dr. Koplan of the Centers for Disease Control. You may proceed. Dr. Koplan. Thank you, Senator Cochran. Good morning. And thank you for your invitation to testify on the national and global problem of antimicrobial resistance and CDC's response to it. Incredible changes in infectious diseases have occurred within our own life span. Many of the diseases that threatened our parents are distant history for our children. In 1942, a 33-year-old woman was hospitalized for a month in Connecticut with a life-threatening streptococcal infection. She was delirious. Her temperature reached almost 107 degrees. Her doctors gave her an experimental drug called penicillin at Grace New Haven Hospital. Her condition began to improve overnight. She was the first woman American civilian that was saved by penicillin. And she died just this past year at the age of 90. The typical population of hospital medical wards was very different in the Thirties than it is today. Today wards are filled with patients who have cancer, heart disease, diabetes, complications of high-blood pressure. In contrast,...