Spectral Tailoring for Boron Neutron Capture Therapy (Stand Alone Dup)

Since the first clinical trials on Boron Neutron Capture Therapy in the 1950s, BNCT research has been mainly focussed on the treatment of (deep-seated) brain tumours, in particular, glioblastoma multiforme. Promising work to treat other cancers at other locations and even other diseases are in progress. Therefore, the chemists, medical doctors, physicists and biologists involved in BNCT are not only continuing to investigate and improve the (brain) clinical results, but are also investigating the new applications in BNCT. The work presented in this thesis is in the field of physics and deals, from three different viewpoints, with obtaining the optimal source neutron energy to optimise BNCT. The optimal source neutron energy is defined such as to obtain as many as possible (n,a)-absorptions due to 10B in the tumours and as low as possible total neutron dose in the healthy tissues and organs at risk. The outcome of this thesis shows that 3 neutron energy regimes should be prescribed in BNCT. As well as the 10 keV epithermal source neutrons, low epithermal source neutrons of around 1 eV and thermal source neutrons with energies of 0.1 eV must be used.

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