Cardiac Drug Development Guide (Methods in Pharmacology and Toxicology)

A comprehensive survey of the latest therapeutic drug discoveries in cardiac and cardiovascular medicine and of the most recent breakthroughs in molecular cardiology. The authors describe the most advanced procedures in cardiac pharmacology today, including in vivo and in vitro whole animal studies, the electrophysiological methods used to study in pacemaker cells, and the application of biochemical principles and technologies to novel therapeutic agents. Also discussed are the methods used to express the ion channels involved in cardiovascular pharmacology, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics in cardiovascular drug development, gender differences in heart failure, and angiogenesis therapies for coronary heart disease.