Transporters in Drug Discovery and Development: Detailed Concepts and Best Practice (Woodhead Publishing Series in Biomedicine)

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

• A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development
• Balanced coverage of molecular biology aspects and functional outcomes
• State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity