Aging Skin: Current and Future Therapeutic Strategies

Aging Skin presents leading-edge strategies to treat problems of aging skin. Current concepts are presented, along with fundamental research detailing the biochemical mechanisms underlying photodamage-the hallmark of aging skin. Based on the premise that aging and senescence occur due to a deterioration of cutaneous repair systems, topics covered include:

-Novel approaches using growth factors that regulate fibrosis to facilitate cutaneous wound repair while preventing solar scar

-Role of matrix metalloproteinases in the repair of photodamage

-Role of angiogenesis and lymphangiogenesis in response to photodamage and strategies to regulate these processes

-DNA repair and oxidative stress-resistant systems that aid in combating aging skin

-Hormonal influences on skin aging, benefit of hormone replacement therapy and role of nutrition

-Nonenzymatic glycation of matrix proteins due to oxidative stress-altering functionality and strategies to block such untoward reactions

-Success of current treatments retinoic acid, dermabrasion, Botox, peels and fillers

-Design of the optimal sunscreen for prevention of photodamage

-New skin-whitening strategies to reduce age spots by influencing melanogenesis