Tissue Repair in a Model of Type 1 Diabetes: Relevance to Microvascular Blood Flow

Delayed tissue repair is a serious complication oflong-term diabetes mellitus. Prior to this studythere was no clear evidence as to how diabeteschanges skin microvascular blood flow or how thesechanges influence tissue repair processes in earlydiabetes. The research undertaken within this projectaimed to investigate the factors that are known tocause long-term vascular complications of diabetesand how these factors contribute to early changes inskin microvascular blood flow. The treatmentprotocols used in this work showed that the action ofthese factors is reversible in the early stages ofdiabetes. These same treatments were also effectivein improving the repair processes in our model ofdiabetes. This research raised the possibility thatearly intervention could prevent microvascularalterations. The information in this book could havesignificant clinical implications for treatingdiabetic patients with long-term vascularcomplications. The results of this study showed asignificant improvement in tissue repair processesusing the principle of non-invasive and easy to applytreatment protocols, which is worthy of furtherinvestigation by medical researchers.