Inhibition of Lipoxygenase and NTPDase Activity by Medicinal Plants: Drug Discovery from Medicinal Plants

In search for new enzyme inhibitors of therapeutic importance, the present study was designed to find inhibitors of two enzymes of therapeutic significance, i.e., Lipoxygenase (EC 1.13.11.12) and NTPDase (Nucleoside triphosphate diphosphohydrolases) (EC 3.6.1.5) enzymes from extracts of medicinal plants used in folk medicine. Lipoxygenase inhibitors are involved in many inflammatory diseases, asthma, cancer, increase immune response to viral and bacterial infection, leukemia, lymphoma and autoimmune disorders. NTPDase inhibitors are currently target for various cardiovascular diseases and some types of cancer.