Withdrawal and Tolerance: Prognostic Significance in DSM-IV Alcohol Dependence(*).: An article from: Journal of Studies on Alcohol
Book Details
PublisherAlcohol Research Documentation, Inc.
ISBN / ASINB0008H6TUK
ISBN-13978B0008H6TU0
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MarketplaceUnited States 🇺🇸
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This digital document is an article from Journal of Studies on Alcohol, published by Alcohol Research Documentation, Inc. on May 1, 2000. The length of the article is 6502 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: Objective: The clinical and research importance of tolerance and/or withdrawal in the diagnosis of substance dependence has been identified as a key area needing clarification. Earlier longitudinal studies did not identify whether diagnoses of alcohol dependence were current or lifetime. In this study, the prognostic significance of the DSM-IV physiological specifier was investigated among cases of alcohol dependence current at the baseline interview. The role of tremors, required in DSM-III and DSM-III-R, was investigated as well. Method: Household residents (N = 130; 57% men) meeting full criteria for current DSM-IV alcohol dependence in a baseline interview were re-interviewed a year later and DSM-IV alcohol dependence was again evaluated. Reliable structured interviews were used to make the diagnoses. The DSM-IV physiologic specifier and its components were tested as predictors of outcome of DSM-IV alcohol dependence, and included an additional definition of alcohol withdrawal that required tremors. Chi-square tests and adjusted odds ratios indicated statistical significance of group differences on outcome. Results: The DSM-IV physiological specifier (tolerance or withdrawal) did not predict 1-year chronicity of DSM-IV alcohol dependence, nor did tolerance when considered separately. However, withdrawal predicted poor outcome (e.g., 1-year chronicity of DSM-IV alcohol dependence). The effect of withdrawal was strengthened when tremors were required as part of the withdrawal syndrome. Conclusions: In contrast to earlier longitudinal research, this study supports the prognostic relevance of one component of the present DSM-IV psysiological specifier--withdrawal. Withdrawal appears to have stronger prognostic meaning when the DSM-III-R version, in which tremors were required, is used. Further studies of the physiological subtype may benefit from studying subjects who have been clearly identified at the baseline evaluation as having a current diagnosis of dependence. (J. Stud. Alcohol 61: 431-438, 2000)
Citation Details
Title: Withdrawal and Tolerance: Prognostic Significance in DSM-IV Alcohol Dependence(*).
Author: Deborah Hasin
Publication:Journal of Studies on Alcohol (Refereed)
Date: May 1, 2000
Publisher: Alcohol Research Documentation, Inc.
Volume: 61 Issue: 3 Page: 431
Distributed by Thomson Gale
From the author: Objective: The clinical and research importance of tolerance and/or withdrawal in the diagnosis of substance dependence has been identified as a key area needing clarification. Earlier longitudinal studies did not identify whether diagnoses of alcohol dependence were current or lifetime. In this study, the prognostic significance of the DSM-IV physiological specifier was investigated among cases of alcohol dependence current at the baseline interview. The role of tremors, required in DSM-III and DSM-III-R, was investigated as well. Method: Household residents (N = 130; 57% men) meeting full criteria for current DSM-IV alcohol dependence in a baseline interview were re-interviewed a year later and DSM-IV alcohol dependence was again evaluated. Reliable structured interviews were used to make the diagnoses. The DSM-IV physiologic specifier and its components were tested as predictors of outcome of DSM-IV alcohol dependence, and included an additional definition of alcohol withdrawal that required tremors. Chi-square tests and adjusted odds ratios indicated statistical significance of group differences on outcome. Results: The DSM-IV physiological specifier (tolerance or withdrawal) did not predict 1-year chronicity of DSM-IV alcohol dependence, nor did tolerance when considered separately. However, withdrawal predicted poor outcome (e.g., 1-year chronicity of DSM-IV alcohol dependence). The effect of withdrawal was strengthened when tremors were required as part of the withdrawal syndrome. Conclusions: In contrast to earlier longitudinal research, this study supports the prognostic relevance of one component of the present DSM-IV psysiological specifier--withdrawal. Withdrawal appears to have stronger prognostic meaning when the DSM-III-R version, in which tremors were required, is used. Further studies of the physiological subtype may benefit from studying subjects who have been clearly identified at the baseline evaluation as having a current diagnosis of dependence. (J. Stud. Alcohol 61: 431-438, 2000)
Citation Details
Title: Withdrawal and Tolerance: Prognostic Significance in DSM-IV Alcohol Dependence(*).
Author: Deborah Hasin
Publication:Journal of Studies on Alcohol (Refereed)
Date: May 1, 2000
Publisher: Alcohol Research Documentation, Inc.
Volume: 61 Issue: 3 Page: 431
Distributed by Thomson Gale
