Ancestral Kinship and cancer in Lastovo Island, Croatia.(Statistical Data Included): An article from: Human Biology
Book Details
Author(s)Igor Rudan
PublisherWayne State University Press
ISBN / ASINB0008IMCU0
ISBN-13978B0008IMCU8
MarketplaceFrance 🇫🇷
Description
This digital document is an article from Human Biology, published by Wayne State University Press on December 1, 2001. The length of the article is 5002 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: Abstract The aim of this study was to compute the average kinship coefficient of cancer cases in an extreme isolate (Lastovo Island, Croatia) and to compare it to the corresponding value for the island's unaffected population. Kinship estimates were obtained by Wright's path method ([phi]) based on pedigree reconstruction and Lasker's coefficient of relationship by isonymy ([R.sub.i]) based on surname distribution. A total of 76 cancer cases were recorded on the island between 1971 and 1995. The unaffected control population of 1144 persons was obtained from the population census in 1971. The data on five ancestral generations were collected from parish registries preserved in the local church, and included 5484 persons born on the island between 1750 and 1970. Both Wright's path method and Lasker's isonymy method indicated significantly greater kinship of female cancer cases than of the unaffected population. Cancer cases with increased values of [R.sub.i] among them and [R.sub.i] among their ancestors inclu ded cancers of the ovary, colon, brain, breast, and prostate and leukemias. This study confirms the role of heredity and common ancestry in the development of cancer, providing a rough insight into their relative importance for specific cancer sites.
Citation Details
Title: Ancestral Kinship and cancer in Lastovo Island, Croatia.(Statistical Data Included)
Author: Igor Rudan
Publication:Human Biology (Refereed)
Date: December 1, 2001
Publisher: Wayne State University Press
Volume: 73 Issue: 6 Page: 871(14)
Article Type: Statistical Data Included
Distributed by Thomson Gale
From the author: Abstract The aim of this study was to compute the average kinship coefficient of cancer cases in an extreme isolate (Lastovo Island, Croatia) and to compare it to the corresponding value for the island's unaffected population. Kinship estimates were obtained by Wright's path method ([phi]) based on pedigree reconstruction and Lasker's coefficient of relationship by isonymy ([R.sub.i]) based on surname distribution. A total of 76 cancer cases were recorded on the island between 1971 and 1995. The unaffected control population of 1144 persons was obtained from the population census in 1971. The data on five ancestral generations were collected from parish registries preserved in the local church, and included 5484 persons born on the island between 1750 and 1970. Both Wright's path method and Lasker's isonymy method indicated significantly greater kinship of female cancer cases than of the unaffected population. Cancer cases with increased values of [R.sub.i] among them and [R.sub.i] among their ancestors inclu ded cancers of the ovary, colon, brain, breast, and prostate and leukemias. This study confirms the role of heredity and common ancestry in the development of cancer, providing a rough insight into their relative importance for specific cancer sites.
Citation Details
Title: Ancestral Kinship and cancer in Lastovo Island, Croatia.(Statistical Data Included)
Author: Igor Rudan
Publication:Human Biology (Refereed)
Date: December 1, 2001
Publisher: Wayne State University Press
Volume: 73 Issue: 6 Page: 871(14)
Article Type: Statistical Data Included
Distributed by Thomson Gale
